Published on
October 19, 2025

The Science of Ketamine Therapy for Depression and Anxiety

Discover how IV ketamine therapy helps treat depression, anxiety, and PTSD safely and effectively.

What Is Ketamine Therapy?

Ketamine therapy is one of the most promising treatments in modern mental health, offering rapid relief for people who haven’t responded to traditional antidepressants.

At Kloud Health, we provide IV ketamine infusions in a calming, medically supervised environment designed to help patients reconnect with themselves—mentally, emotionally, and physiologically.

How It Works

Originally developed as an anesthetic, ketamine acts on the glutamate system, not serotonin. It stimulates NMDA receptors and increases synaptic plasticity, allowing the brain to form new neural connections and “rewire” itself out of depressive patterns.

At Kloud, infusions are administered by anesthesia-trained providers to ensure precise dosing, medical monitoring, and a deeply restorative experience.

Clinical Benefits

  1. Rapid mood improvement (often within 24 hours)
  2. Relief for treatment-resistant depression
  3. Reduction in suicidal thoughts
  4. Diminished PTSD and anxiety symptoms
  5. Long-term mood stabilization when done in series

Patients typically undergo a 6-infusion series over 3–6 weeks, followed by periodic maintenance sessions as needed.

The Kloud Experience

Our Beverly Grove clinic features sound-insulated private rooms, low lighting, and a serene atmosphere designed to evoke calm. Every session combines medical precision with sensory comfort—a true mind-body reset.

Supported by Science

Reference Study:
Zarate, C. A. Jr., et al. (2006). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry, 63(8), 856–864.
Link to study (PubMed)

This landmark study by the National Institute of Mental Health and Yale University found that a single IV infusion of ketamine produced rapid antidepressant effects in patients with treatment-resistant depression—often within 24 hours.
Subsequent research has replicated these findings in hundreds of clinical trials worldwide.

Supported by Science

Ketamine therapy represents a major evolution in how we approach mood disorders—rooted in neuroscience, delivered with compassion.

Schedule a consultation at Kloud Health to learn if IV ketamine therapy could help you rediscover balance and clarity.

Memberships